Also referred to as 'AIE', an event or experience which frustrates one so much that one instantaneously develops AIDS.
Tom: So how did you get AIDS, sexually or by AIDS Inducing Experience?
Harry: AIE. I spent 7 years on a 15,000 piece puzzle, to find that the last piece was missing!! WTF!! FML!!
Tom: Omfg, I developed AIDS just listening to that!!