2 definitions by Matty P.

/verb/ to get rid of someone or something that is annoying, like Dandruff.

/noun/ when given to someone or said in reference to being a gift it is a signal (or code) that they should disappear with no trace.
"I've Desonexed all night and she still didn't get the hint. I can't seem to get rid of her!"

"Jimmy, that guy's starting to work my last nerve. I want you you give him some Desonex for me."
by Matty P. October 20, 2006
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referring to a person/object/situation that locates itself beside you or in your proximity (literal or figurative) that is less than desired.
"Yo man, that new girlfriend of yours is suckin' you dry. You need to brush that dandruff right off! Seriously, Desonex the chick!"

"Mikey, you're freakin' dandruff! You always show up at the worst time!"
by Matty P. October 20, 2006
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