A twincestious yaoi pairing from Hetalia featuring the Italian twins N. Italy (Feliciano Vargas) and his older brother S. Italy (Lovino Vargas)
As they are part of the same country and were unified it can be called canon, also in the anime and manga Himaruya hinted Lovino's protection over his brother when challenging Germany
Person 1: My OTP is Spamano!
Person 2: I prefer Itacest!!