1 definition by Dominus Pollux

Cranial-Rectal Entanglement Syndrome (also known as Anal-Cranial Entanglement Syndrome, or ACES) is a disorder which is characterized by someone who is incapable of performing a simple task due to pure stupidity or an apparent misplacement and, therefore, disuse of their cerebellum and cerebrum.

Esp. applies when someone has one job and cannot complete it properly, if at all.
Karen suffers from such a severe case of Cranial-Rectal Entanglement Syndrome, she has a visible tan-line around her neck.

I’ve run into a catch-22 due to two of the people I rely on having ACES.
by Dominus Pollux February 6, 2019