1 definition by Betty C and Betty Jo
When a male gets overly anxious about an event. Similar to a woman "getting her panties in a bunch".
John: OMG, this is a complete disaster! What am I going to do?
Jude: Settle down man, don't get your dick in a knot.
Jude: Settle down man, don't get your dick in a knot.
by Betty C and Betty Jo February 26, 2008