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1.
To agree to something in a cool and convenient way.
Can I come to Friday night Jimaymay?
Yuiop!
by the real mo October 10, 2010
 
2.
Yuiop is basically the word Yup but is made by sliding your finger across the keyboard from "Y" to "P"

Pronounced: Yope (Nope with a "Y" instead of an "N")
Text Message Ex 1:

Girl 1: Hey are you still going on Xbox Live?
Girl 2: Yuiop be on in 2 minutes

Text Message Ex 2:

Girl 3: Watcha Doin?
Girl 4: Nuttin Really...u?
Girl 3: Readin...
Girl 4: Cool
Girl 3: Yuiop
by The Lost Whovian December 09, 2013