Abbreviation for You're On Your Own. Something you say after a stupid person says YOLO, letting them know that you have no part in what stupid thing they're about to do.
Guy 1: Hey, I'm gonna go bungee jump off a bridge, YOLO!
Guy 2: Uh, YOYO bro. Go be stupid by yourself.
by ilikechickennn August 22, 2012
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Medical slang, but can be used anywhere: Means: You're on your own. Used in a hospital on the day of discharge as in the phrase "OOB,OTD, YOYO" : Out of Bed, Out the Door, You're on your own. Can be used by parents of colleged aged kids, or by someone breaking up with someone else. .
I've had it with you, YOYO!
by DoctorSteve September 13, 2006
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Stands for: Your only young once.
Tom: Hey I bet you won't chug that whole bottle.
Ben: ah idk...
Tom: yoyo bro
Ben: glug* glug* glug*
by Alex (the man) Rosentreter October 3, 2008
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"You're Only Young Once"

YOYO is a motivational phrase that nourishes the pursuit of happiness in young people. Unlike similar abused phrases, such as YOLO, YOYO remains positive and is seldom used by prepubescent girls who seek an excuse to expose their chest or by idiots who need a catchphrase for their Jackass-like stunts.

But there's much more to YOYO...

YOYO is not merely a term. It's a way of thinking. It's a state of mind. The basic principle of YOYO states that the journey, not the destination, is what permeates us with happiness. Thus, the start of the journey, the beginning of our life is of vital importance. The end could be anything. The end could be a slow, painful, lung cancer... or a sudden plane crash. Ergo, the most rational course of action is to give more importance to our youth and not the end.
Adriana tried to butt-rape me with a broom. I said no. She said "Come on! YOYO!"

My friend used to be a meth addict. All he needed to heal was to hear me say, "John, YOYO." - He's been clean for 2 years now.
by pcordon August 17, 2012
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When you need a poo really badly so you yoyo it in and out of your bumhole
Damn man ive been yoyoing for about an hour, can i use the toilet yet m8
by madmuff January 10, 2017
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A totally amazing man with an uncanny skill at fencing, and unmistakably smooth with the ladies. If you know someone named yoyo then "Hide yo wife, Hide yo kids" .....
by yobopobo May 28, 2014
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