Medical slang, but can be used anywhere: Means: You're on your own. Used in a hospital on the day of discharge as in the phrase "OOB,OTD, YOYO" : Out of Bed, Out the Door, You're on your own. Can be used by parents of colleged aged kids, or by someone breaking up with someone else. .
I've had it with you, YOYO!
Killing oneself by jumping off a bridge in Ithaca, New York usually because of Cornell University's crushing work load. The bridges cross the deep gorges that border campus. Use of term is highly discouraged by the Cornell University administration.
I'm failing all my courses! I'll never be a doctor now! I want to gorge out.