Jack Blade quote from Tropic Thunder. His character was experiencing withdrawl from cocaine and he was tied to a tree. Crazy shit ensued.

Basically, It means your mother sleeps with everyone and has deseases between her legs, and most likely, you are unwanted crotchspawn.
"Your mother is a cankerous whore!"
"Damn."
"Hey, remember that time I called your mother a cankerous whore? I didn't mean it man, she's a nice lady." - Tropic Thunder
by Allie-Rose March 12, 2009
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1.When you are telling a story and have engaged a listener but realize that the climax of the story is not nearly as enthralling as the build up, this phrase is used to complete your story with an unexpected slam on the listener instead of trailing it off at the end and disappointing yourself and your audience.

2. Alternative ending to a "and then I found five dollars" type of story.
"Today I got to work a little late and there were rumors about my company letting some people go. This afternoon, my boss called me into his office and sat me down across from him with a solemn look on his face... and well, he didn't fire me, but the point of the story is, your mother's a whore."
by scass May 17, 2010
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the end of the world's funniest joke as said my Sean Connery (played by Darrel Hammond) in a Saturday Night Live Celbrity Jeoprady Sketch (Alex Trabeck Played by Will Ferrel)
Sean:Whats the Difference and a Mallord with a cold?

Alex: what

Sean: One's a sick duck, I can't remember how it ends, but your mothers a whore.
by tessa{!!!!!} October 13, 2007
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