1. "Shall we do it?" in Japanese.
2. a 2ch fad that came from a yaoi comic which featured an image of a man wearing a jumpsuit pulling down a zipper. This is commonly used in 2ch flashes with the head of Mona or some other 2ch mascot, often times with a speech bubble saying "Come On!" Is used occasionally at the american *chans but not as often.
There's not really much i can say that hasn't been mentioned above