This is an abbreviation that asks the question, as stated above, what Niel Patrick Harris would do in x situation. So, basically, if something is going down, one would ask WWNPHD?
"Dude, look at the lifeguard! She's smokin'. Would you do her?"
"I don't know, but WWNPHD?"
It is said of the situation where a person has the bad luck to make contact with his testicles against an undefined surface or object, intentioned or not.
Given the nature of the word, it is more appropriate to design cases where the interaction is made with a moving object, for example, a ball.
Although it is extremely painful for the victim, it tends to be considerably funny to people who witness it.
Today in the baseball game the pitcher took a nutshot; the baseball hit him in the nuts.
Man, I just watched the funniest nutshot video ever.