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Contraction of the greeting "What's up?" which is a contraction of "What is up?" If you're really pressed for time, greet someone with a "sup"?. In any case, the greeter is rhetorically asking you what is going on in your life. Roughly synonymous with hello but less hip.
Hipster1: Wussup?
Hipster2: Nuttin'.
Hipster1: Word.
Hipster2: Word is bond.
wussup by Edward January 6, 2004
Related Words

wussmonger 

A creator or promoter of wussiness, usually with their mere existence.
Darryl is such a wussmonger! I could beat him up any day!
wussmonger by Jojo the Assassin October 25, 2009
The squished together slang word "wassup," also known as (wussup, wassssssssssssssup, wosssssssssssssup) and others originally stemming from the words " what is up " either meaning (how are you), (what are you doing) or even both at the same time.

Time went by, and the expression "what is up" became too long to say, type and text for the average lazy person. Therefore wassssssssup was invented.

Following this point, budweiser took this idea and made it their international slogan used on adverts, said by various strange frog people.

WASSSSSSSSSUP was then the word of the world and everyone, wherever they were, whether in an igloo in iceland, or in a whole in tikrit, (iraq), or in a cave in afghanistan, or even in some shitty trailer park in America, or Buckingham palace everyone could say "wassssssssup" without necesarilly understanding it.
daniel: " wassssssssssssssssssssup?"
alex: " not much, you?"
wussup by jimmeny cricket January 6, 2004
A Nocternal creature that only stay up long enought to collect light for its' crazy physics experiment.
The Wossum awakes!
wossum by Sarge February 19, 2004

dass wussup 

"That's what's up", usually referring to something excting, and something that is of your interest.
"We're gunna party, and get laid!"

"Dass Wussup!"
dass wussup by Nicholexcore October 27, 2008
It's long for 'sup.

Also part of the Buddweiser commercial fad.
- Wassup dawg?!
- Yo dawg, 'sup?
wussup by zorpidus January 7, 2004