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1.
To play Blizzard's World of Warcraft so much that you fail your classes, life, etc.
"Chris hasn't left his room in two weeks. I hope he doesn't wow out of school this semester."
by george mason August 21, 2006
 
2.
A deep spacing out while playing World of Warcraft, often while grinding, and becoming consciously aware 1-10 hours later saying "wtf."
Steve:"Man, I was grinding this mob, and the next thing I know it was 3 hours later and I was eating chips and thinking 'wtf'."

John:"Woah man, you had a major WoW Out."
by Maz0r January 17, 2010