Top Definition
A word that can be substituted for any verb with humorous effect. Made popular by the 2004 X-Box game Ninja Gaiden, in which, upon approaching any object, the game prompted you to interact with it.
"Quick, interact with that ladder before that dude fucks you up. You suck at interacting."

"If you dont shut up my cock is going to interact with your mouth."
by PISTOLsINstack July 24, 2004

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