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1.
An exclamation of mild surprise or amazement, always used in combination with 'gee', as in 'Gee, whilikers!'.
Gee, whilikers! That's a big plate of pasta!
by Jim Jensen October 05, 2007
 
2.
An old southern term used as a code word during the prohibition era to signal that law enforcement was nearby at a speakeasy. It has since been used to express surprise or dismay.
"Gee Whilikers!"
by rapanui19 September 01, 2011