Top Definition
1. Similar to when people get mossed, people get wayne'd
(refers to indianapolis colts receiver reggie wayne), who is just that much better than randy moss
Person one: Yeah bro, we were playing football, i jumped up three feet in the air,and caught it one handed.

Person two: NO WAY! DAMN! YOU WAYNED HIS ASS

beastownedmossedpeyton manningjim caldwellboss
by reggiewayneonthemhoes March 07, 2010

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Being duped, tricked, hoodwinked into thinking one thing but having the exact opposite actually occur
I waited and waited for the phone call that never came, i guess i was Wayned.

I Wayned that guy out of 20 bucks.

She was Wayned at the altar.
by musqueam May 27, 2009

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To be under the influence of alchohol.
"Let's go get wayned."
"I'm soo wayned!"
by God March 28, 2005

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To get drunk, To drink a copious amount of alcohol
"Whoa, this guy is gonna past out in a ditch, he must be wayned."
by the_doc October 01, 2006

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1. The feeling of helplessness that occurs after being screwed over by Wayne State University
1. Class schedule: 'incomplete'

Administrator: Sorry, the classes you have selected are full, please register for them next semester.

You: But I submitted all of the paperwork to you early!

Administrator: Oh, I lost it. Too bad for you.

You: fml. just got wayned.

2. Administrator: you must pay $200 in late fees. your tuition was late

you: I paid it on time, the exact amount you told me to.

Admin:That was the wrong number. You should have double checked with me 'later'.

You: what?

Admin: $200. Now.

You: fml. wayned again.
by jolly_rancher5 April 05, 2014

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Getting scuttled on copious amounts of alcohol.
"Oh god, my head is killing me."
"Why?"
"Me and the girls got Wayned last night on some Woodstock."
"Did you get a root?"
"Obviously!"
by Rollergirl November 03, 2005

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To ruin a conversation full of laughs and jokes with a really lame joke.
Wow. Wayne wayned the conversation with that lame waynism.
by Gjg2424 November 19, 2016

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