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Make 7-Up Yours! 

A 7-Up TV advertisement from 1999-2005, which featured comedian Orlando Jones wearing a green t-shirt that said "MAKE 7" on the front of it, and "UP YOURS!" on the back of it. Jones would then walk around and tell people to "Make 7-Up Yours!", where he would get responses like an angry insulted guy yelling "Same to you!"

This advertisement actually became so popular that shirts similar to the one Jones wore became available for sale through many gag-gift catalogues, record/CD stores, and Media Play entertainment centers.
ORLANDO JONES: I'm the guy who makes 7-Up, and I also write the advertising. I just came up with a great new slogan - "Make 7-Up Yours!" *points at front of shirt* "Make 7", *points at back of shirt* "Up Yours!"...

up yours 

An expression used in return to an action or comment that was offensive. It is referring to something being stuck up the other person's butthole.
person #1: Yo, you're a fucking bitch!
person #2: Up yours!
up yours by jillybean November 5, 2003

up yours nigger 

Up yours nigger is a line that was said by the greatest grandma in history from the movie Blazing Saddles
Sheriff: Good morning ma'am ain't it a lovely morning
Greatest grandma: Up yours nigger {walks away salty}
~later~
Greatest grandma: good evening sheriff! Sorry about the up yours nigger. I hope this apple pie is a small thank you for your ingenuity ang courage for beating that horrible Mongo (PS mongo is a awesome character to and remember Mongo straight)
Sheriff: thank you good night
Greatest grandma: of course you'll have the good taste not to mention that I spoke to you
Sheriff: of course good night
up yours nigger by HamsterInAirfryer September 30, 2022

up yours 

Equivalent to "go to hell", "fuck off", etc.
Person 1: See? This never woulda happened if you'd just listened...
Person 2: Up yours!
up yours by Oh the insanity... November 6, 2003

up yours 

-another way of telling someone to shut up or telling them to fuck off
-Your teeth are crooked as fuck
-Up yours
up yours by nicole April 20, 2004

Up yours 

The most INFAMOUS definition of the commonly used word up (↑).
Means shove it up your ass or worse, using only innocent words - it is EQUIVALENT to fuck you!

If you are not using this as an insult, you are a stupid fucking idiot who cannot even count! Hahahahahaha!
Julia, unfortunately explained, "I am sorry, but you have not been selected to the Elite Community. I hope you can try next year..."
Yaha shouted, "UP YOURS! YOU MUSTHERFUCKING ILLEGITIMATE COCKWANKING HEAP OF ABOMINABLE DOGSHIT - YOUR WORDS ARE FUCKING STUPID"

Yaha used it correctly, and insulted her