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1.
A rancher/farmer expression. The smart animals, and the leaders, stay apart from the crowd.
Always drink upstream from the herd.
by David A April 02, 2004
 
2.
virgin territory.

Ranchers use the water upstream from the herd because it is clear and clean.

Downstream would be in the path of pollution/destruction.
"I'll just stay upstream from the herd till things quiet down."
by Ogma April 02, 2004
 
3.
Someone original.

As opposed to downstream from the herd, which is someone stupid and likely to be drinking water infested with pee or crap.
That Eminem, he's upstream from the herd.

Yeah, but everyone downstream isn't retarded.
by The Man April 09, 2004