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1.
A person holding an alcoholic beverage in each hand. Often seen at keggers, ball games, or other places where the line for a drink is rather long. Individuals will often get two drinks at a time. When one is finished they get back in line. They can then enjoy the second beverage while waiting. That way they never run out and risk ruining their buzz.
Guy #1: Dude, are you two fisting it again?
Guy #2: Hell yeah! It takes 20 minutes to get a beer in this place.
by Wiseman July 14, 2006
 
2.
1. Fisting one body cavity, with two hands. 2. Fisting two body cavities, with one hand each.
1. My wife love's it when I am two fisting her pussy.

2. I love two fisting my skanky neighbor, anally and vaginally. I rule!
by Cunty Fresh Fanatic October 30, 2010