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Throwing up and diarrhea at the same time.
Man I was so sick last night throwing up and diarrhea I didn't know which end was gonna let go next. My friend you had a major case of twist and shout!!!
by L Ray August 29, 2009
The act of putting your fingers into your lovers anus, grabbing hold, then you twist your hands and pull your hand out causing them to shout in pain
Steve gave Betty such a good twist and shout that her asshole began to bleed
by Tom December 09, 2004
a method of masturbation brought to light in an episode of the HBO series Real Sex whereby a man uses a twisting motion of his hand on his shaft and then lets out a vocal shout
"Is Jamie going to come out with us on a fun pass?"

"No, he'll probably just sit at home all night doing the Twist and Shout."
by Squall1 February 03, 2010