Top Definition
describes the difficulty sleeping caused by reading Twilight books or watching Twilight movies, usually a result of an inability to stop thinking about Twilight.
*Facebook IM Conversation*

-What are you doing up so late?

-I can't sleep. I just saw Eclipse for the second time today. I'm too excited.

-Oh, so you have twisomnia.
by MyLifeIsTwilight July 01, 2010

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