Bro Desiree is a tweaker , she be staying up til like 8am
by dray7282 February 19, 2018
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Someone using Crystal meth or ice are referred to as tweakers. They are commonly referred to as tweaking out as in a state of paranoia or moving and twitching profusely.
Look at the tweakers peeking out of the blinds.

Look ! That tweakers been down this aisle 17 times in 2 minutes.
by MizzuzKotzz×3 September 17, 2018
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Is a person that's looking for something that isn't there.
The tweaker was looking for the bit of crack that he had already smoked.
by Facetious Gatherer August 3, 2021
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Someone who's high on Methamphetamine, dope, shyt, icecream, crystal, Annie, clear, glass, shake n bake, crank, speed, And nom nom just to list the different names it has so far. It causes the user to be unable to sleep, become paranoid, a lot of the times to an unrealistic extent where they honestly believe shadow people are out to get them or there are shadow people in the trees, some will pick at their face, pick at what they believe are "Meth Mites" in their skin, which will in return cause lesions on the skin, their jaw will uncontrollably "rock" from side to side, this is worsened when talking or concentrating on whatever random project they're doing, most will have a dirty home, very few will have an extremely clean one, those will also feel like no one can see that they are clearly "wired for sound" and might vigorously clean things outside their home, like their SUV/Car/Truck, in doing so they will also do so in a scatter brain, squirrel chasing nuts kind of fashion. These meth heads will always be around the exact same group of people. Occasionally you will see the same set of different faces show up for a period of time, which most likely will be the supplier.
"The girl JayJay is going to lost that kid and her apartment, all because she'd rather be a tweaker and to meth."

"That tweaker Lachelle looked insanely bad the other night when the cops showed up. She ended up showing she wasn't really Jayjays friend at all and they still "trick" together for small bags of "dope"."

"How has no one taken that beautiful baby girl out of there yet with her "tweaker" mother neglecting her and having all those strange men and smoking all that "meth" around her?"
by J_DiSilvio92 April 5, 2022
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a name/insult to say a person looks like they do drugs.
jimbo:omg look at that tweaker
random man:*awardly stares*
by screechturnr March 14, 2023
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A northern term that originated in Akron,Ohio used to describe a druggie or a weirdo like a tranny or something.
Dude a Tweaker🤣🤣🤣
by User3318310746827 April 18, 2022
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