When somebody directly interferes with a girl's ability to have sex with a guy. It's essentially the female version of a cock block.
Sarah: I can't believe I just got twat blocked by my friend. I'm so pissed!

Hannah: Some friend!
by Michael Hammond May 4, 2013
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Twat being another word to describe the vagina, someone who twat blocks or is a twat blocker is a female who gets in the way of another female friend and a male.
Damn it Tina! Just because Jake broke up with you doesn't mean you have to twat block me now!
by ThatRegret April 10, 2010
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Twat blocking is when a girls friends hang around , continue being annoyance, and otherwise prevent a guy from making his way with his chic.
Cunt Blocked, Bitch Blocked, Cherry Blocked,Vag Block,
(1) Patrick was twat blocked by Becky's friends.
(2) After dinner and a movie Jennie and Patrick returned to Jennie's room to find 3 of her friends waiting with the movie "The Devil Wears Prada" and a bowl of Pop Corn. Patrick Said, Damn I just got "Fucking Twat Blocked"
(3) John had blue ball because he had just been Twat Blocked by Cynthia's friends.
by yarden1234567 September 20, 2008
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When a friend keeps a Bi chick and/or lesbian from getting laid by her girlfriend.
Friend 1: "Come on guys lets go to the movies!"

Girlfriend 1: "No ive got a beter idea. Me and my girl will stay here and you can go to the movies."

Friend 2: "Oh come on guys, it'll be fun!"

Girlfriend 2: "Fun for you maybe. You fuckin Twat Block!"
by LeggoMyEggoBITCH!!!! May 18, 2010
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When a female prevents another female from scoring with a man.
Emma is such a twat block. Danny and I were supposed to be on a date, but she showed up and they talked the entire time!
by cindy yetti March 11, 2008
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It is pretty much the same thing as cock-blocking, just on the opposite side of the spectrum. It's for the ladies!

I'm getting some sexually tonight. Last night Jamie was twat-blocking all night!
by Steven Capone January 16, 2008
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(v 1) When a female interferes* with someone, typically a male who is getting acquainted with, conversing with, or hooking up with a member of the opposite sex.
(v 2) any action that impedes or stalls another's "game", "mack", or "pimp manuver"

(n) any female one who prevents another person from getting to know someone.

*Often intentionally
(1) Jim was talking to Lisa. That is until Jims little sister twat blocked him when she asked why he needed two girlfriends.
(2) My ex-wife twat blocks me every chance she gets. I hate her.
by Solar1 April 7, 2009
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