Twackered Share definition Flag The feeling one has when one has been awake for to long on a variety of substances, primarily ecstasy, cocaine, and/or crystal meth. Dude I took my last E pill five hours ago and now I'm just straight twackered. Twackered by Rellik Uzi August 14, 2010 0 0 Get merch Get the Twackered mug. Buy Now — $32.95 See more merch