Top Definition
a combination of the words "twack" and "acne". its the acne you get from being twacked out for too long and usually not taking care of yourself.
person 1: "dude, how long has chris been tweaking?!"
person 2: "idk but he's been on one for a while..."
person 1: "I can tell, he's got twacne and hasn't showered in days!"
by divine sally March 04, 2010
when a female has acne on her twat
Yo Man, That hoes got mad twacne!!!
by Kevin McNally June 02, 2008

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