To be truffin' is to have reached a state of absolute bliss or nirvana. In order to powertruff, one can use alcohol or narcotics. Most often, people can be found truffin' at parties, or social gatherings, where the likelihood of achieving such a state is exponentially increased. In other words, to be truffin' is to be utterly happy, uninhibited and content with life. Once you begin truffin', you immediately become a truffer, sometimes referred to as "the truff".
Drunk friend 1: Yo son, is you truffin' or what?
Drunk friend 2: Hell yeah I'm truffin'! Boi I AM the truff!
Drunk friend 1: Word?
Drunk friend 2: Word.