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1.
Used by Notorious BIG, commonly misconstrued as a fictional drug similar to Prozac, it is simply a variation of the word track. BIG was in fact dangerous on most tracks, and clearly ahead of his time. Izzle Kizzle my Nizzle. Snoop, you unoriginal bastard.

Dangerous on trizack / Leave your ass flizzat (meaning flat).
by Cesar Armas September 12, 2005
 
2.
A fictitious anti-depressant from the family of Prozac, Paxil, etc. Used mostly by the Notorious B.I.G. and his crew, circa 1996.
From "Mo Money Mo Problems":

"Like thizat, dangerous
on trizack, leave your ass cozak"
by Nima February 14, 2004