Top Definition
One of the funniest sound effects in all of history. A "thwub" is a sound you hear in "dub-step" music, often repeatedly
I was channel-jumping on a radio, and I heard a loud and heavy "thwub-thwub-thwub-thwub" on one of the stations. I almost died laughing.
by VaderTheIntimidator November 29, 2012
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