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all their skin in the game

This describes a situation in which someone is risking everything.
The bomb squad has all their skin in the game defusing the van.

Don't hate the game, hate the playa 

When a guy gives up on a girl because she's banging someone else
Lalo: I could have had her.
Max: Bro, don't hate the game, hate the playa.

Married to the Game 

To put work above all else in life. Dedication to a job, craft or building one's skill.

Hustling, paper chasing.
I don't have time to date or take vacations because I'm married to the game, and the grind don't quit.

thegamingbeaver

One of the best youtubers in all of history
Yo thegamingbeaver's videos are fucking awesome

best teeth in the game 

Anthony Fantano, "The Internet's Busiest Music Nerd".
Melon has the best teeth in the game.

Don't hate the player, hate the game

Don't blame the person for finding out a way to beat the system , blame the system for being beatable
Person 1: WAIT, WHAT!? HE'S NOT ALLOWED TO DO THAT! IT'S NOT FAIR!
Person 2:Well it doesn't say you can't do that.
Person 1:But it's not fair
Person 2: Don't hate the player, hate the game