A nickname for the city of Miami, FL. Originated from "M-I-AYO", another nickname given to the city.
Person 1: "Ayo you tryna slide to the yayo today?"

Person 2: "Naw bruh, i gotta bond my lil bruh"
by Zambookie January 4, 2012
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I needed some skrill, so I started slangin' that yayo powder.
by Kimo November 26, 2002
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the substance that Hannah Montana uses before every show : )
So what you see
Is only half the story
There's another side of me
I'm the girl you know
But I'm someone else too
If you only knew
yayo
by Hairy Vagina December 19, 2007
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cocaine and one hell of a song by Andre Nickatina
ayo for yayo
walk aroud wit yayo
all n my nasal
i musta been crazed yo
by MJ April 7, 2005
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Slang term for cocaine, actually a misspelled version of llello.
I'm a wannabe coke head, so I misspell llello as yayo.
by m1ndj0b March 9, 2003
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Cocaine. This is a wonderful drug, but be careful. If you snort it wrong you can die, and come downs are a bitch.
"Ay foo I is so ayo fo yayo!"
("Hey fool I am so crazy about cocaine.")
by skeetyii November 21, 2007
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mispelled version of llello , which Tony Montana uses as a slang for Cocaine
gimme an eightball of your best llello
by Nefar1ous August 10, 2003
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