When somebody directly interferes with a girl's ability to have sex with a guy. It's essentially the female version of a cock block.
Sarah: I can't believe I just got twat blocked by my friend. I'm so pissed!

Hannah: Some friend!
by Michael Hammond May 4, 2013
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When a female prevents another female from scoring with a man.
Emma is such a twat block. Danny and I were supposed to be on a date, but she showed up and they talked the entire time!
by cindy yetti March 11, 2008
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It is pretty much the same thing as cock-blocking, just on the opposite side of the spectrum. It's for the ladies!

I'm getting some sexually tonight. Last night Jamie was twat-blocking all night!
by Steven Capone January 16, 2008
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(v 1) When a female interferes* with someone, typically a male who is getting acquainted with, conversing with, or hooking up with a member of the opposite sex.
(v 2) any action that impedes or stalls another's "game", "mack", or "pimp manuver"

(n) any female one who prevents another person from getting to know someone.

*Often intentionally
(1) Jim was talking to Lisa. That is until Jims little sister twat blocked him when she asked why he needed two girlfriends.
(2) My ex-wife twat blocks me every chance she gets. I hate her.
by Solar1 April 7, 2009
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Twat being another word to describe the vagina, someone who twat blocks or is a twat blocker is a female who gets in the way of another female friend and a male.
Damn it Tina! Just because Jake broke up with you doesn't mean you have to twat block me now!
by ThatRegret April 10, 2010
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similar to a cock block; a 'girl' friend stepping in to run off the ugly girl your stuck talking to; More likely to happen at a club/bar
Girl: 'Man, that girl wouldn't step off, and she was ugly!'Friend: "Thanks for twat blocking"Girl: "'yeah, anytime'BOTH: (continue drinking excessively)
by tellulah January 31, 2008
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when a woman cock blocks another woman. TWAT BLOCK.
GIRL - HEY WANT TO GO TO MY HOUSE TONIGHT?
BOY- SURE WANNA GO WRITE NOW?
GIRLS FRIEND- SORRY WE GOT TO GO WALK MY DOG.
BOY- OK THEN BYE.

TWAT BLOCK
by TRIXSTER45 December 7, 2010
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