For men, their own pebis.
For women, their favorite plastic toy.

Try to keep in mind this phrase means your MAIN squeeze, NOT the boyfriend/girlfriend you squeeze every once in a while!!
by stimpy October 16, 2003
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Your best friend, home skillet, buddy for life, homie home dog, home skillet biscuit, friend for life,usually of Mexican heritage, around 5 feet tall, often named Andrea because you guys are BFFS and he/she is the real MVP. All in all, your uber duper extra best friend.
Yo that girl Andrea is my main squeeze, we been friends since all the way back in 2010
by Thugmaster3k August 26, 2015
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jackson is a cool kid and he likes to send memes especially about the holocaust he is a terrorist and is apart of the mafia and likes to rape young children.
hey look it's jack my main squeeze the terrorist
by jsbshhahaha bahah June 29, 2019
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“yo peter is my main squeeze

“that wasn’t very main squeeze of you”

crank that by soulja boy is main squeeze”

“stephanie and stefanie are main squeeze”
by heffanator420 July 2, 2021
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Referring to the main woman that gets you to ejaculate so strongly that your engulfed prostate promotes an involuntary spasm of your gluteus maximus.
Having sex with my hoe is cool but it's nothing compared to sex with my main squeeze. For example, when you're hungry, you get that fast food and it does the job but it's nothing compared to that restaurant-style filet mignon.
by Wor Izzo November 23, 2020
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