depending upon the region it generally means two people either made out or fucked.
"Did you hear about Mary and Joey? They hooked up last weekend"
by billybobjoebobsteve August 4, 2005
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to hook up is to do anything from make-out to have sex, with someone you are not in a relationship with
I dont think i'll ever hook up with him, even if im drunk
by hookup hoar October 10, 2005
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any form of getting some type of action, such as, making out, feeling things, or oral pleasure or sex between 2 people. "A hook up" is whats referred to as doing those things when your not going out with anyone
Guy:"yo, i hooked up with kristin last night!"
Guy 2:"Nice, what did you do?"
Guy1:"we only got to third"
by A jerzy boy December 6, 2003
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Casual sexual activity. Sex while not in a relationship with eachother. Similar to a "one-night stand," but it can happen repetedly. As long as the two people are not serious about eachother, and they have sex, it's hooking up.
Me and John hooked-up last night.

Did you and Mary hook-up at the party?

We aren't going out or anything-- we just hook-up from time to time.

How long have they been hooking up?
by SandyCheekssss October 23, 2009
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1) to get together with someone with the intention of dating or having sexual relations with them.

2) to meet up with someone to hang out.

3) to "hook someone up" means to provide that person with some kind of item or service, often of an illegal nature.
1) "I hooked up with my girlfriend when she used to live next door to me."

2) "We'll hook up with you guys later at Cassidy's."

3) "Hook me up with an Alpine sometime if you can."
by hipster April 18, 2006
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Sex for its own sake; when one or both of its participants doesn't want or doesn't know if they want a committed relationship but are horny. Usually, sex early on, especially on the first date, is the hallmark sign of a hook-up.
Dude 1: How'd your Tinder date go last night?

Dude 2: Pretty good. We got dinner and drinks and went back to my place.
Dude 1: Nice! Did you hook-up?
Dude 2: Yeah, dude. She was pretty hot.
by JayMoolah September 17, 2017
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Yanks use 'hook up' differently to the rest of the English-speaking world. They use it in a sexual context or providing an item for somebody that's usually dodgy. Everyone else uses it in the context of meeting someone.
Hook up:

1) I hooked up with him in New York. We made love all night!

2) Hey! Hook a brother up with some dope!

3) I hooked up with my mate in London. I hadn't seen him in years.
by Cortez The Killer November 23, 2007
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