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Filipino phrase originally referring to the Holy Family (Jesus sus, Mary mari, Joseph osep). Usually used as an expression of surprise, amazement, or utter disbelief.

Others say the entire phrase: "Hesusmaryosep!"

Akin to the phrase "Oh my God!"
Susmariosep! Ano bang ginagawa mo diyan?! (Susmariosep! What are doing there?!)
by jobango January 13, 2009