Its a O.G latino Word(OVIOUSLY IN SPANISH)that means to not agree or give assent to something.
-#1 ESE-"ay homez, you see that fat bitch over there?"
-#2 ESE-"HELL YEAH I SEE THAT BITCH! HOW CAN YOU MISS HER AY."
-#1 ESE-"SHE SAYS SHE WANTS TO DOME YOU UP HOMEZ."
-#2 ESE-"WTF!! SPENSA HOMEZ! SPENSA!!