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1.
To not like the situation, to be disgruntled/upset

happens when things are pooched
- Im so soured over you right now!
- Soured over the situation!

Tom: Man this party blows...
Jim: Im so soured right now
by Andyman1818 March 19, 2006
 
2.
To be intoxicated.

Synonyms: Drunk, Sauced, Shitfaced, Hammered, Trashed, Plastered.
Oh man, he's had one shot too many. He's soured.
by Matt Nguyen March 21, 2005