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1.
wimp, pussy, weak
cant fight or is scared to do somthing bad
You are a little sissy ass bitch.Ill kick ur ass.
by Alex Pate January 30, 2003
781 326
 
2.
straight girly guy
by anonymous September 02, 2003
599 250
 
3.
a boy or man who enjoys little girls clothing. Especially babyish clothing. Lots of frills. Not always straight or gay. Likes to be treated like a babygirl. Likes tea partys and playing with dollys.
Boys who likes to dress in babydoll clothes. Wears diapers and sucks on a pacifier. Like a baby crossdresser
by Tabitha December 04, 2004
667 366
 
4.
An affectionate female nickname derived from the word sister. Sissy is a common nickname for a female sibling. It can also be a nickname given to a girl by others that she has cared for or behaved sisterly towards. The nickname implies that the girl is a sister or is regarded as such by family and friends. All in all, a sweet, caring girl :-)

See sister, sis, girl, female
Little Sis: I love you, Sissy.

Sissy: Awww, I love you too.
by Sissy September 02, 2004
430 259
 
5.
a man who acts like a girl
Look at Paul fussing over the wedding's colour scheme, he's such a sissy.
by Juzzamacrum April 06, 2012
55 39
 
6.
Originally defined as "wimp", "pussy" or "weak" the word sissy has morphed into the perfect def'n of a Brazilian footballer.
Brazilian guy: "Hey man, that Brazzer baller is down crying for mom. He's hurt bad!"
Normal guy: "Nah dude, he's just a sissy. Get out the spray. His vagina is sore. Stop complaining and be a man (bitch slaps Brazzer)"
by BrazzerMike May 13, 2013
20 33
 
7.
A very close and dear friend. Someone who is, or whom you consider, to be a sister. Someone who will never let you down and be by your side for life.
My sister gets mad when I call her 'sissy', but I know deep inside she loves me!
by diorznotwar June 13, 2007
112 152