Sam-e is the type of girl any man would love to come accross, literally and figuratively. She is a beautiful girl, typically, with exotic eyes and a great smile. Sam-e is usually a name given to a girl who is sexually promiscuous, and has experience in the sack. Typically found in the local bars, blacked out, about to get some ass, or both.

Be cautious when approaching Sam-e as you never know what kind of mood she will be in; sometmes she is very friendly, other times, she will rip you a new asshole, and then make you buy her a shot.
Jermaine: Hey did you see Sam-e at the bar last night?

NiNi: Yea she was stumbling into a cab. Luckily she was bringing home a rando...hopefully he had a rubber!
by Beth87 January 15, 2011
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A very good looking lad, he is the lead singer of an english band called Test icicles
Fat Emo Girl Fag: Hey, whos the fit singer of test icicles?
Fan: sam e danger you fat emo fag
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A man who walks around the city of Pittsburgh Looking for male prostitutes. He especially has a fascination with men himself, for he is gay. He is referred to in many songs in the local rap scene.
"Sam E-Dub wont do shit
Cause Ill hit him with my nine and he'll respect"
-Nine and Eight
by Andre Taggart March 16, 2007
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Adopted, dumb and thinks everyone likes him but he is a full on shit. He is secretly a girl but goes as non bionary. He has a huge fat crush on Jenna r.
Imaging having to be friends with a Sam E
by October 31, 2020
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