Top Definition
to confront someone with hostility
so then she gonna run up on me talkin about i owe her some money.
by shatda shekem March 17, 2005
to jump, or momentarily attain a hidden position and then compromise your position with bad intent
so what make's you think imma run up on you with a nine
-50 Cent
by atowneightynizzle November 12, 2003
To try to make a move or have sex with somebody
"Whaddup with you and me girl? When we gon' chill?"

"Nigga,Dont even try to run up on my shit!!"
by Bobscout January 06, 2006

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