To be in a dominating position where one has total or a large share of control over an industry, business, enterprise or most often a drug spot.
Chump: Yo look at that Escalade on 22s, that must be the cash money millionaires
Lil Nigga: Nah that's poppi, he runs shit down on 25th son
"You think this is a joke motherfucker? I RUN shit, not you. The game is MINE! (shoots competition in the face)"