To be in a dominating position where one has total or a large share of control over an industry, business, enterprise or most often a drug spot.
1)

Chump: Yo look at that Escalade on 22s, that must be the cash money millionaires
Lil Nigga: Nah that's poppi, he runs shit down on 25th son

2)

"You think this is a joke motherfucker? I RUN shit, not you. The game is MINE! (shoots competition in the face)"
by wza August 06, 2005

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