When you are so confused about a situation that it quite perplexes you
Also can be used in a situation where you are left speechless
Hudson told justin that the peanut butteralready had a hole in it and that Daisy (his dog) hadnt even been around him that day. Justin said, "Hey Hudson I'm quite quanderious about what you just said"
It is said of the situation where a person has the bad luck to make contact with his testicles against an undefined surface or object, intentioned or not.
Given the nature of the word, it is more appropriate to design cases where the interaction is made with a moving object, for example, a ball.
Although it is extremely painful for the victim, it tends to be considerably funny to people who witness it.
Today in the baseball game the pitcher took a nutshot; the baseball hit him in the nuts.
Man, I just watched the funniest nutshot video ever.