"Pussyo" is a term coined by the gang culture in the major parts of urban london. pussyo refers to an individual who lacks physical and mental strength, and who may or may not stand up for themselves, being generally intimidated or scared of others.
"yo blud, yur a f**kin pussyo"
"yeh boi, yur a pussyo, an ima cut you up!"
this proceeds in the beating or attacking of the "pussyo"