Top Definition
A combination of pussy, and ho. (obviously) Simply a dis or derogatory term used by today's youth to make fun of each other. It basically means that you are a little, weak wimp, or bitch which is also used to say that the accused may not want to participate in the group's activities or is possibly afraid of getting in trouble.
"I can't believe he wouldn't get high with us. What a pussy-ho."
by GoodFella520 January 16, 2007

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