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someone who has taken a lot of pill-form drugs. pilled up refers to the way the person looks after taking drugs. similar to the expression drugged up, but is used to describe a higher drug class, i.e. ecstasy is a class A drug and is a pill. can also be used to describe a general drug high. common expression used at raves and in clubs.
He was so pilled up last night
That is one pilled up chav
you look pilled up
by lemox June 09, 2005