A word used for anything in general. Mostly known for drugs though.
"You smoke that piff?"

"That new sandwich at Mcdonalds is piff."
by Azurebaijan March 28, 2004

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Can be used as an ad lib, verb, sound effect, anything you want it to be.
Guy #1: Dude, what the piff just happened?
Guy #2: That guy just piffed you hardcore.
Guy #3: Yeah, that guy was just like "piff" with his gun and it was over with.
by Fitzman June 03, 2009

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to "piff" is to run up behind someone, flick your wrist and in turn hit the person in the back of the head, then run away in a childish manner
haha you just got piffed
by dani g October 18, 2006

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Piff is another name for marijuana.
Are you going to light up the piff?
by Chris aka(Mr. Cee) December 31, 2005

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Smokin Purple Haze Dro weed etc
U Smell Dat Piff Or U Smokin Dat Piff
by DJ Piezo January 09, 2006

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tight, cool or the latest hip thing.
Aw Dawg, those jeans are piff!
by catmandu January 01, 2005

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crack...or may be used to describe somethin dope
yo that new juelz santana mixtape is straight piff
by mad$een February 22, 2005

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