Top Definition
The act of to pulling your underpants out of your ass crack or fixing yourself after being the recipient of a wedgie.
I named this tight leopard print thong "Master" because it keeps me picking cotton all day.
by Dick Thimble October 18, 2010
picking up white girls (if you're a black guy)
- yo Tyrone, wat u did last saturday nite, dawg?
- I was in da club, picking cotton.
by UrbanPrick January 04, 2012
the act of doing an excess of tasks in order to do something else.
"dude i've been picking cotton all day just so i can go out tonight"
by ryan boyd November 03, 2007
the act of being rediculously drunk; the remaining moments of conciousness before passing out
Friend "Hey, are you drunk?!"
You "Nahhh, I was drunk an hour ago. Now I'm picking cotton"

by Frederikson c304 January 29, 2006
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