A person who has taken and abused drugs for so long that they achieve a permanent state of "highness" whether they are on drugs or not. They are literally a little bit "munted" forever...
by TinkaBell January 9, 2017
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a person who has smoked so much weed that they are now pemanently fried
she smoked so much weed that now she is a permafry
by XxbertxX September 1, 2006
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Getting baked too often to where you have the effects without smoking, makes you feel stupid and lost at times
Me and my bro smoked for 10 days stright we are permafried
by Ace-_-420 August 5, 2011
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Where you smoke so much weed, you feel, even when youre not stoned, a feeling of physical and mental exhaustion.
Ive smoked Ambrosia 2 weeks straight, and im waking up everyday permafried.
by mitch connor II September 9, 2011
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smoking so much weed that you are known to have S.R.D. (stupid retarded disorder). also known as "William Fisher."
that kid is permafried!
by willie wonka520 July 11, 2008
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When youve done too many drugs in a short amount of time youre permanently fucked up/ retarded

Also known as a Matthew Ramo.
"Dont be a matt ramo, wait a couple weeks before you trip again or you'll be permafried."
by Fanxis August 15, 2017
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