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Italian, usually said in reference to 'buddy, friend, mate'. Also in the diaspora used to describe Italians from same village your ancestors came from.
"You know Domenico, don't you? He's a paisano (from the same village)"

"Hey paisano"
paisano by MatteoP December 9, 2008
Related Words
A word used by italians toward other italians meaning "Italian brother" sometimes shortened to Paisan.
"Capisci Paisano, Si o no"
"Ay paisan, how ya doin"
paisano by tony two toes February 16, 2005
Generally describes a person from the same origin as oneself.

Paisano originates from the Italian lauguage, in which it means "Brother." It is also the equivalent to "Homie" in the U.S. and often shortened to "Paisa" in slang terms.
Cristian and Jessica are both from Panama.

Therefore Jessica can call Cristian a Paisano. (or Paisa)
Paisano by ut_baby2012 November 10, 2009
"I think."
-me

"Hey paisano!"
-a mafian walking past a fellow mafian
paisano by Dave June 14, 2004
A Slur often towards blacks/Italian's of the bottom class.
"Get outta here you filthy Paisano!!!"

Paisano/Paisan

Paisano/Paesano/Paisan -Italian(n) referring to another Italian(n)who is from the same village or area/region in Italy.
Countryman
Alfredo is a Paisano/Paisan also from (name of ancestral homeland-village) or region of Italy; as in Marchegiano (a person from the region of Le Marche).