Top definition
The act of having sex. It has its roots in a 50 cent song.
"This bitch won't stop calling me since we one-o-sixed."
"I am tired as hell, I was u one-o-sixing all night".
by Jiggatastic August 15, 2003
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2
I gotta go meet up with my one-o-six.
by Phatastic August 18, 2003
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