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1.
A person who has smoked too much opium and disintegrated their brain to the point of being retarded.
Jessi is wicked retarded, but what can you expect, shes an ohead.
by anonymous January 23, 2004
11 3
 
2.
A person who is highly addicted to Oxycontin aka O.C.s.
O- Heads usually crush up the pills and snort them, even possibly injecting them. If you deprive an O- Head of their "daily dose", you are in for three kinds of hell!
Amanda is a real O- Head- She spends half her paycheck on those little pink pills!
by LaLaLovesYou January 05, 2007
1 8